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[A successful two-stage treatment with CDDP and CPT-11 for pancreatic neuroendocrine carcinoma with liver metastasis].

Abstract
A 59-year-old man was diagnosed as having a pancreatic carcinoma with synchronous liver metastasis at initial surgery. After wedge resection of liver tumor for histopathological analysis and gastro-jejunostomy, he was treated with 3 cycles of combined systematic chemotherapy consisting of CDDP and CPT-11, because of histopathological diagnosis confirming a neuroendocrine carcinoma of the pancreas. After chemotherapy, there was no recurrence and the primary tumor was reduced in size. Therefore, pancreatico-duodenectomy was performed as a curative treatment in two stages. During the follow-up, the patient has been alive without any signs of recurrence for 20 months since the diagnosis. Recently, several consecutive chemotherapies have been an effective modality to improve a poor prognosis for unresectable neuroendocrine carcinoma.
AuthorsSatoru Nomura, Akira Togawa, Takashi Kaiho, Kazuyasu Shinmura, Shinji Yanagisawa, Ryo Okamoto, Masaki Nishimura, Shun-ichi Tsuchiya, Masaru Miyazaki
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 36 Issue 11 Pg. 1897-900 (Nov 2009) ISSN: 0385-0684 [Print] Japan
PMID19920396 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antineoplastic Agents
  • Antineoplastic Agents, Phytogenic
  • Irinotecan
  • Cisplatin
  • Camptothecin
Topics
  • Antineoplastic Agents (administration & dosage)
  • Antineoplastic Agents, Phytogenic (administration & dosage)
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Camptothecin (administration & dosage, analogs & derivatives)
  • Carcinoma, Neuroendocrine (pathology, therapy)
  • Cisplatin (administration & dosage)
  • Combined Modality Therapy
  • Humans
  • Irinotecan
  • Liver Neoplasms (secondary)
  • Male
  • Middle Aged
  • Pancreatic Neoplasms (pathology, therapy)

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