Abstract | BACKGROUND: METHODS: We conducted a case-control study including 618 HCC cases and 712 controls to evaluate the associations between these two polymorphisms and HCC risk for Guangxi population by means of TaqMan-PCR and PCR-RFLP analysis. RESULTS: We found that individuals featuring the XPD genotypes with codon 751 Gln alleles (namely XPD-LG or XPD-GG) were related to an elevated risk of HCC compared to those with the homozygote of XPD codon 751 Lys alleles [namely XPD-LL, adjusted odds ratios ( ORs) were 1.75 and 2.47; 95% confidence interval (CIs) were 1.30-2.37 and 1.62-3.76, respectively]. A gender-specific role was evident that showed an higher risk for women (adjusted OR was 8.58 for XPD-GG) than for men (adjusted OR = 2.90 for XPD-GG). Interestingly, the interactive effects of this polymorphism and AFB1-exposure information showed the codon 751 Gln alleles increase the risk of HCC for individuals facing longer exposure years (Pinteraction = 0.011, OR = 0.85). For example, long-exposure-years (> 48 years) individuals who carried XDP-GG had an adjusted OR of 470.25, whereas long-exposure-years people with XDP-LL were at lower risk (adjusted OR = 149.12). However, we did not find that XPD codon 312 polymorphism was significantly associated with HCC risk. CONCLUSION: These findings suggest that XPD Lys751Gln polymorphism is an important modulator of AFB1 related-HCC development in Guangxi population.
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Authors | Xi Dai Long, Yun Ma, Yun Feng Zhou, Jin Guang Yao, Fu Zhi Ban, Yong Zhi Huang, Bing Cheng Huang |
Journal | BMC cancer
(BMC Cancer)
Vol. 9
Pg. 400
(Nov 17 2009)
ISSN: 1471-2407 [Electronic] England |
PMID | 19919686
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Aflatoxin B1
- Xeroderma Pigmentosum Group D Protein
- ERCC2 protein, human
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Topics |
- Adult
- Aflatoxin B1
(adverse effects)
- Aged
- Asian People
- Carcinoma, Hepatocellular
(etiology)
- Case-Control Studies
- Female
- Genetic Predisposition to Disease
- Genotype
- Hepatitis B
(complications, epidemiology)
- Hepatitis C
(complications, epidemiology)
- Humans
- Liver Neoplasms
(etiology)
- Male
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Single Nucleotide
- Risk Factors
- Sex Factors
- Xeroderma Pigmentosum Group D Protein
(genetics)
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