Abstract | PURPOSE: We investigated the global gene expression in a large panel of pancreatic endocrine tumors (PETs) aimed at identifying new potential targets for therapy and biomarkers to predict patient outcome. PATIENTS AND METHODS: Using a custom microarray, we analyzed 72 primary PETs, seven matched metastases, and 10 normal pancreatic samples. Relevant differentially expressed genes were validated by either quantitative real-time polymerase chain reaction or immunohistochemistry on tissue microarrays. RESULTS: CONCLUSION: Our results strongly support a role for PI3K/Akt/mTOR pathway in PET, which ties in with the fact that mTOR inhibitors have reached phase III trials in neuroendocrine tumors. The finding of differential SSTR expression raises the potential for SSTR expression to be evaluated as a marker of response to somatostatin analogs. Finally, we identified FGF13 as a new prognostic marker that predicted poorer outcome in patients who were clinically considered free from disease.
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Authors | Edoardo Missiaglia, Irene Dalai, Stefano Barbi, Stefania Beghelli, Massimo Falconi, Marco della Peruta, Lorenzo Piemonti, Gabriele Capurso, Alessia Di Florio, Gianfranco delle Fave, Paolo Pederzoli, Carlo M Croce, Aldo Scarpa |
Journal | Journal of clinical oncology : official journal of the American Society of Clinical Oncology
(J Clin Oncol)
Vol. 28
Issue 2
Pg. 245-55
(Jan 10 2010)
ISSN: 1527-7755 [Electronic] United States |
PMID | 19917848
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- TSC2 protein, human
- Tuberous Sclerosis Complex 2 Protein
- Tumor Suppressor Proteins
- Proto-Oncogene Proteins c-akt
- PTEN Phosphohydrolase
- PTEN protein, human
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Topics |
- Adolescent
- Adult
- Aged
- Carcinoma, Islet Cell
(genetics)
- Cell Line, Tumor
- Down-Regulation
- Female
- Gene Expression Profiling
- Humans
- Male
- Middle Aged
- Neoplasm Metastasis
- PTEN Phosphohydrolase
(genetics)
- Pancreatic Neoplasms
(genetics)
- Proto-Oncogene Proteins c-akt
(genetics)
- Signal Transduction
- Tuberous Sclerosis Complex 2 Protein
- Tumor Suppressor Proteins
(genetics)
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