Increased ceramide synthase 2 and 6 mRNA levels in breast cancer tissues and correlation with sphingosine kinase expression.

Abstract	Intervention in the ceramide metabolic pathway is emerging as a novel means to regulate cancer and to modify the activity of chemotherapeutic drugs. We now study mRNA expression levels of the six ceramide synthase (CerS) genes in breast cancer tissue. CerS2 and CerS6 mRNA was significantly elevated in breast cancer tissue compared to paired normal tissue, with approximately half of the individuals showing elevated CerS2 and CerS6 mRNA. A significant correlation was found between CerS2 and CerS6 expression, and between CerS4 and CerS2/CerS6 expression. Moreover, patients that expressed higher CerS2 or 4 mRNA levels tended to show no changes in sphingosine kinase 1 levels, and likewise patients that expressed no change in CerS2 or CerS4 mRNA levels tended to express higher levels of sphingosine kinase 1. Together these results suggest an important role for the CerS genes in breast cancer etiology or diagnosis.
Authors	Racheli Erez-Roman, Reut Pienik, Anthony H Futerman
Journal	Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 391 Issue 1 Pg. 219-23 (Jan 01 2010) ISSN: 1090-2104 [Electronic] United States
PMID	19912991 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright	Copyright 2009 Elsevier Inc. All rights reserved.
Chemical References	Membrane Proteins RNA, Messenger Tumor Suppressor Proteins CERS2 protein, human CERS6 protein, human Sphingosine N-Acyltransferase Phosphotransferases (Alcohol Group Acceptor) sphingosine kinase
Topics	Adult Aged Aged, 80 and over Breast Neoplasms (enzymology, genetics) Carcinoma, Ductal (enzymology, genetics) Female Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Humans Membrane Proteins (biosynthesis, genetics) Middle Aged Phosphotransferases (Alcohol Group Acceptor) (biosynthesis) RNA, Messenger (biosynthesis) Sphingosine N-Acyltransferase Tumor Suppressor Proteins (biosynthesis, genetics)

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