Abstract |
Heat shock is a well-known stress response characterized by a rapid synthesis of a set of proteins which are responsible for protection against stress. We examined the role of temperature on the growth of cricket paralysis virus, a member of the family Dicistroviridae, in insect cells. Heat shock caused an induction of heat shock protein-encoding mRNAs in uninfected cells but not in infected cells. While viral RNA and protein were abundant during heat shock, virion formation was inhibited at higher temperatures. The different susceptibility to pathogens at different temperatures is likely a crucial feature of host-pathogen interaction in cold-blooded animals.
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Authors | Randal C Cevallos, Peter Sarnow |
Journal | Journal of virology
(J Virol)
Vol. 84
Issue 3
Pg. 1652-5
(Feb 2010)
ISSN: 1098-5514 [Electronic] United States |
PMID | 19906924
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Topics |
- Animals
- Cell Line
- Drosophila
- Electrophoresis, Polyacrylamide Gel
- Insect Viruses
(pathogenicity)
- Temperature
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