Insulin pump therapy management in very young children with type 1 diabetes using continuous subcutaneous insulin infusion.

Abstract

BACKGROUND:

Compared to older children and adolescents very young patients with type 1 diabetes represent a unique population. We analyzed the age-dependent characteristics and parameters of continuous subcutaneous insulin infusion (CSII) in children under 6 years of age with type 1 diabetes.

METHODS:

We evaluated metabolic control and pump-dependent characteristics in 46 children with type 1 diabetes after 0.89 +/- 0.62 years of CSII.

RESULTS:

Metabolic control significantly improved after CSII initiation (glycosylated hemoglobin, 8.12 +/- 1.24% vs. 7.30 +/- 0.67%; P < 0.05), without increased risk for diabetic ketoacidosis or hypoglycemia. Interestingly, very young patients required bigger boluses than expected, especially in the morning and at the afternoon snack.

CONCLUSIONS:

These data support the need to personalize pump-dependent characteristics, especially in very young children with type 1 diabetes, in order to optimize CSII therapy in this unique age group of patients.

• Authors: Ivana Rabbone, Andrea Scaramuzza, Adriana Bobbio, Riccardo Bonfanti, Dario Iafusco, Fortunato Lombardo, Sonia Toni, Stefano Tumini, Franco Cerutti
• Journal: Diabetes technology & therapeutics (Diabetes Technol Ther) Vol. 11 Issue 11 Pg. 707-9 (Nov 2009) ISSN: 1557-8593 [Electronic] United States
• PMID: 19905886 (Publication Type: Journal Article)

Chemical References

• Glycated Hemoglobin A
• Hypoglycemic Agents
• Insulin

Topics

• Age Factors
• Child, Preschool
• Diabetes Mellitus, Type 1 (drug therapy)
• Female
• Glycated Hemoglobin (metabolism)
• Humans
• Hypoglycemic Agents (administration & dosage, adverse effects)
• Insulin (administration & dosage, adverse effects)
• Insulin Infusion Systems (adverse effects)
• Longitudinal Studies
• Male