Abstract | PURPOSE: METHODS: Twenty patients with predominantly cystic craniopharyngiomas were admitted from 1981 to 2006. Eleven patients had [(32)P] intracavitary irradiation by stereotactic injection or Ommaya cyst instillation as the primary treatment, and the remaining nine had the same internal irradiation as an adjuvant treatment after tumor resection. A calculated irradiation dose of 400 approximately 500 Gy per once was delivered to the cyst wall. CONCLUSION: The patients were followed up ranging from 36 to 336 months; no operative morbidity or mortality was found from [(32)P] intracavitary irradiation. Fourteen patients (70%) had tumor progression and required further two to four times intracavitary irradiation. All 20 cases achieved tumor shrinkage or stabilization with effective outcome 3-6 months after the last [(32)P] therapy. For patients with cystic craniopharyngioma, [(32)P] administration by stereotactic injection or Ommaya cyst instillation is a safe and helpful option, which could improve the life quality, prolong the life span, and enhance the survival rate of cystic craniopharyngioma patients.
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Authors | Rong Zhao, Jinglan Deng, Xiaoyan Liang, Jin Zeng, Xiaoyuan Chen, Jing Wang |
Journal | Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
(Childs Nerv Syst)
Vol. 26
Issue 5
Pg. 669-74
(May 2010)
ISSN: 1433-0350 [Electronic] Germany |
PMID | 19904543
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
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Topics |
- Brachytherapy
(methods)
- Child
- Child, Preschool
- Craniopharyngioma
(pathology, radiotherapy)
- Cysts
(surgery)
- Female
- Humans
- Male
- Phosphorus Radioisotopes
(therapeutic use)
- Pituitary Neoplasms
(radiotherapy)
- Stereotaxic Techniques
- Suction
- Tomography, Emission-Computed, Single-Photon
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