High concentrations of resistin in the peripheral blood of patients with acute basal ganglia hemorrhage are associated with poor outcome.

Abstract

PURPOSE:

Resistin increases in peripheral blood of patients with intracerebral hemorrhage (ICH). We sought to evaluate its relation with disease outcome.

MATERIALS AND METHODS:

Thirty healthy controls and 86 patients with acute ICH were included. Plasma samples were obtained on admission. Its concentration was measured by enzyme-linked immunosorbent assay.

RESULTS:

Thirty-two patients (37.2%) died from ICH in a week. The plasma resistin level (24.2 +/- 9.7 ng/mL) in patients was significantly higher than that (8.8 +/- 2.4 ng/mL) in healthy controls after adjustment by age, sex, hypertension, diabetes mellitus, hyperlipidemia, and body mass index using analysis of covariate (F = 9.507, P = .003).A univariate correlation analysis found Glasgow Coma Scale (GCS) score and ICH volume, but a multivariate linear regression only selected GCS score (t = -4.587, P < .001) to be related to plasma resistin level. On a multivariate logistic regression, plasma resistin level (odds ratio = 1.257, 95% confidence interval = 1.058-1.492, P = .009) was an independent variable predicting 1-week mortality. A receiver operating characteristic curve identified that a plasma resistin level greater than 26.3 ng/mL predicted 1-week mortality of patients with 81.2% sensitivity and 81.5% specificity (P < .001). Areas under curves of GCS score and ICH volume were not statistically significantly larger than that of plasma resistin level (P > .05).

CONCLUSIONS:

Increased resistin level is found after ICH, in association with a poor clinical outcome.

• Authors: Xiao-Qiao Dong, Yue-Yu Hu, Wen-Hua Yu, Zu-Yong Zhang
• Journal: Journal of critical care (J Crit Care) Vol. 25 Issue 2 Pg. 243-7 (Jun 2010) ISSN: 1557-8615 [Electronic] United States
• PMID: 19903588 (Publication Type: Journal Article)
• Copyright: Copyright (c) 2010 Elsevier Inc. All rights reserved.

Chemical References

• Resistin

Topics

• Acute Disease
• Aged
• Area Under Curve
• Basal Ganglia Hemorrhage (blood, mortality)
• Case-Control Studies
• Enzyme-Linked Immunosorbent Assay
• Female
• Glasgow Coma Scale
• Humans
• Linear Models
• Male
• Middle Aged
• Multivariate Analysis
• Prognosis
• Resistin (blood)
• Sensitivity and Specificity