Abstract | BACKGROUND: METHODS: One hundred and twenty five female patients with migraine attending the emergency department received 0.15 mg of methylergonovine intravenously. Pain intensity, heart rate, blood pressure, and methylergonovine side effects were checked 5, 10, 15, 30 and 60 minutes after drug administration. An additional 0.075 mg dose of methylergonovine was administered to those patients who did not experienced relevant pain relief 15 minutes after dosing. RESULTS:
Pain intensity decreased markedly from the first minutes after dosing, the 74.4% of patients being pain free at 60 minutes. Only seven patients required an additional dose of methylergonovine. Nausea and vomiting were the most relevant side effects related with methylergonovine administration (84% of patients). A substantial decrease (10 to 25 mmHg) in systolic blood pressure values was observed in 56% of the patients. A significant correlation (p < 0.0001) was found between the decrease in pain intensity and the reduction of systolic blood pressure. CONCLUSION: Although limited by the non-controlled design of the study, our data suggest that intravenous methylergonovine can be an effective and safe drug in the management of severe migraine attacks in the emergency room.
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Authors | Alfredo I Niño-Maldonado, Gary Caballero-García, Wilfrido Mercado-Bochero, Fernando Rico-Villademoros, Elena P Calandre |
Journal | Head & face medicine
(Head Face Med)
Vol. 5
Pg. 21
(Nov 08 2009)
ISSN: 1746-160X [Electronic] England |
PMID | 19895705
(Publication Type: Journal Article, Multicenter Study)
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Chemical References |
- Oxytocics
- Methylergonovine
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Topics |
- Adult
- Analysis of Variance
- Blood Pressure
(drug effects)
- Emergency Service, Hospital
- Emergency Treatment
- Female
- Humans
- Methylergonovine
(administration & dosage, therapeutic use)
- Middle Aged
- Migraine Disorders
(drug therapy)
- Oxytocics
(administration & dosage, therapeutic use)
- Pain Measurement
- Treatment Outcome
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