Crosstalk between angiogenesis, cytokeratin-18, and insulin resistance in the progression of non-alcoholic steatohepatitis.

Abstract

AIM:

To elucidate the possible crosstalk between angiogenesis, cytokeratin-18 (CK-18), and insulin resistance (IR) especially in patients with non-alcoholic steatohepatitis (NASH).

METHODS:

Twenty-eight patients with NASH and 11 with simple fatty liver disease (FL) were enrolled in this study and underwent clinicopathological examination. The measures of angiogenesis, CK-18, and IR employed were CD34-immunopositive vessels, CK-18-immunopositive cells, and homeostasis model assessment of IR (HOMA-IR), respectively. The correlations of these factors with NASH were elucidated.

RESULTS:

Significant development of hepatic neovascularization was observed only in NASH, whereas almost no neovascularization could be observed in FL and healthy liver. The degree of angiogenesis was almost parallel to liver fibrosis development, and both parameters were positively correlated. Similarly, CK-18 expression and HOMA-R were significantly increased in NASH as compared with FL and healthy liver. Furthermore, CK-18 and HOMA-IR were also positively correlated with the degree of neovascularization.

CONCLUSION:

These results indicate that the crosstalk between angiogenesis, CK-18, and IR may play an important role in the onset and progression of NASH.

• Authors: Mitsuteru Kitade, Hitoshi Yoshiji, Ryuichi Noguchi, Yasuhide Ikenaka, Kosuke Kaji, Yusaku Shirai, Masaharu Yamazaki, Masahito Uemura, Junichi Yamao, Masao Fujimoto, Akira Mitoro, Masahisa Toyohara, Masayoshi Sawai, Motoyuki Yoshida, Chie Morioka, Tatsuhiro Tsujimoto, Hideto Kawaratani, Hiroshi Fukui
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 15 Issue 41 Pg. 5193-9 (Nov 07 2009) ISSN: 2219-2840 [Electronic] United States
• PMID: 19891019 (Publication Type: Journal Article)
• Copyright: 2009 The WJG Press and Baishideng. All rights reserved.

Chemical References

• Keratin-18

Topics

• Adult
• Case-Control Studies
• Disease Progression
• Fatty Liver (etiology, physiopathology)
• Female
• Homeostasis (physiology)
• Humans
• Insulin Resistance (physiology)
• Keratin-18 (physiology)
• Liver (blood supply, physiopathology)
• Male
• Middle Aged
• Neovascularization, Pathologic (physiopathology)
• Signal Transduction (physiology)