Topiramate overdose: a case report of a patient with extremely high topiramate serum concentrations and nonconvulsive status epilepticus.

Abstract

We report the case of a 21-year-old man with idiopathic generalized epilepsy who ingested about 8,000 mg of topiramate (TPM) in a suicide attempt. On admission to the hospital he had a nonconvulsive status epilepticus and received 4 mg lorazepam i.v. He recovered rapidly despite an initial TPM concentration of 144.6 microg/ml. To our knowledge, this is the first report of a patient who survived such a high TPM concentration. The case indicates that nonconvulsive status epilepticus could be a manifestation of TPM intoxication.

• Authors: Christian Brandt, Heike Elsner, Nora Füratsch, Matthias Hoppe, Esther Nieder, Bernhard Rambeck, Alois Ebner, Theodor W May
• Journal: Epilepsia (Epilepsia) Vol. 51 Issue 6 Pg. 1090-3 (Jun 2010) ISSN: 1528-1167 [Electronic] United States
• PMID: 19889015 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Topiramate
• Fructose

Topics

• Drug Overdose
• Fructose (analogs & derivatives, blood, poisoning)
• Humans
• Male
• Status Epilepticus (blood, chemically induced, diagnosis)
• Suicide, Attempted
• Topiramate
• Young Adult