Itraconazole treatment of nonmeningeal coccidioidomycosis in children: two case reports and review of the literature.

Abstract

Coccidioides immitis causes a wide range of disease in humans. Fluconazole and itraconazole are effective treatments. Clinical evidence suggests that itraconazole is equivalent or superior to fluconazole in treating osteoarticular infections in rates of cure and recurrence. We report 2 cases of coccidioidomycosis involving bone in children successfully treated with itraconazole oral solution. Itraconazole oral solution is effective in treating nonmeningeal coccidioidomycosis in children, particularly skeletal disease, and infections that are refractory to fluconazole.

• Authors: James D Homans, LaShonda Spencer
• Journal: The Pediatric infectious disease journal (Pediatr Infect Dis J) Vol. 29 Issue 1 Pg. 65-7 (Jan 2010) ISSN: 1532-0987 [Electronic] United States
• PMID: 19884875 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Antifungal Agents
• Itraconazole

Topics

• Administration, Oral
• Antifungal Agents (administration & dosage, therapeutic use)
• Child
• Child, Preschool
• Coccidioides (drug effects, isolation & purification)
• Coccidioidomycosis (diagnosis, drug therapy, microbiology)
• Female
• Humans
• Itraconazole (administration & dosage, therapeutic use)
• Male
• Osteomyelitis (drug therapy, microbiology)
• Treatment Outcome