Efficacy of 2% ibopamine on the dilation of patients with pseudoexfoliation syndrome.

Abstract

PURPOSE:

To compare the mydriatic effects of 2% ibopamine and collyrium containing 10% phenylephrine + 0.5% tropicamide and to study the associated drug in patients with ocular pseudoexfoliation (PEX) syndrome.

METHODS:

This was a prospective, comparative, interventional clinical study. The study group consisted of 20 patients with ocular PEX syndrome. Intervention procedures included administration of 10% phenylephrine-0.5% tropicamide versus 2% ibopamine versus 2% ibopamine followed by the combination drug. Main outcome measurement was mydriatic efficacy measured in terms of mean pupil diameter. Adverse effects on intraocular pressure (IOP) were measured with a Goldmann applanation tonometer. Mean premedication pupil diameters in all patients were less than 3.5 mm.

RESULTS:

Instillation of 10% phenylephrine-0.5% tropicamide caused significantly greater mydriasis than 2% ibopamine (pupil diameters: 6.17 mm, SD=1.14 versus 5.33 mm, SD=1.34; p<0.001). Combined use of both collyria significantly increased mydriasis (7.19 mm; SD=0.69) compared with that induced by either of the products alone (p<0.001). Inadequate mydriasis (pupil diameters < 5.5 mm) was observed in 2 patients after administration of 10% phenylephrine-0.5% tropicamide and in 10 following instillation of 2% ibopamine, but the addition of 10% phenylephrine -0.5% tropicamide to ibopamine-treated eyes resulted in adequate dilation in all cases. IOP increases of 4 mmHg over baseline values were observed in 12 (60%) patients after 2% ibopamine.

CONCLUSIONS:

In patients with ocular PEX, instillation of 2% ibopamine exerts a significant additive effect on mydriasis induced with 10% phenylephrine-0.5% tropicamide with only minimal increases in IOP.

• Authors: Gian Luca Scuderi, Federico Regine, Andrea Perdicchi, Angela Turtoro, Maria Teresa Contestabile
• Journal: European journal of ophthalmology (Eur J Ophthalmol) 2010 Jan-Feb Vol. 20 Issue 1 Pg. 120-3 ISSN: 1120-6721 [Print] United States
• PMID: 19882519 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Drug Combinations
• Mydriatics
• Ophthalmic Solutions
• Phenylephrine
• ibopamine
• Tropicamide
• Deoxyepinephrine

Topics

• Aged
• Deoxyepinephrine (administration & dosage, analogs & derivatives)
• Drug Combinations
• Exfoliation Syndrome (complications)
• Female
• Humans
• Intraocular Pressure
• Male
• Mydriatics (administration & dosage)
• Ophthalmic Solutions (administration & dosage)
• Phenylephrine (administration & dosage)
• Prospective Studies
• Pupil (drug effects)
• Tonometry, Ocular
• Treatment Outcome
• Tropicamide (administration & dosage)