Improved vaccination against Newcastle disease by an in ovo recombinant HVT-ND combined with an adjuvanted live vaccine at day-old.

Abstract	The continuous outbreaks of fatal Newcastle disease (ND) in commercial poultry flocks demonstrate that current vaccination strategies are not fully efficacious and should be improved by new generation of vaccines. In this context, maternally immune conventional layer chickens were vaccinated in ovo with a turkey herpesvirus recombinant expressing the fusion (F) gene of NDV (rHVT-ND) and/or at day-old with an apathogenic enterotropic live ND vaccine co-administrated or not with chitosan by oculo-nasal route. The induced vaccinal immune responses and conferred protection against a challenge with a circulating NDV velogenic viscerotropic strain were evaluated. The innovative rHVT-ND/live ND-chitosan vaccination regimen provided the best protection against mortality and morbidity as well as the strongest reduction of virus shedding that could be related to the higher measured cellular immune response and digestive antibody-mediated immunity.
Authors	Fabienne Rauw, Yannick Gardin, Vilmos Palya, Sofia Anbari, Sophie Lemaire, Marc Boschmans, Thierry van den Berg, Bénédicte Lambrecht
Journal	Vaccine (Vaccine) Vol. 28 Issue 3 Pg. 823-33 (Jan 08 2010) ISSN: 1873-2518 [Electronic] Netherlands
PMID	19879230 (Publication Type: Journal Article)
Chemical References	Adjuvants, Immunologic Antibodies, Viral Vaccines, Attenuated Vaccines, Synthetic Viral Fusion Proteins Viral Vaccines Chitosan
Topics	Adjuvants, Immunologic (administration & dosage, pharmacology) Administration, Intranasal Animals Antibodies, Viral (blood) Chickens Chitosan (administration & dosage, pharmacology) Cloaca (virology) Genetic Vectors Herpesvirus 1, Meleagrid (genetics) Newcastle Disease (immunology, prevention & control) Ovum (immunology) Spleen (immunology) Survival Analysis T-Lymphocytes (immunology) Vaccination (methods) Vaccines, Attenuated (administration & dosage, genetics, immunology) Vaccines, Synthetic (administration & dosage, genetics, immunology) Viral Fusion Proteins (genetics, immunology) Viral Vaccines (administration & dosage, genetics, immunology) Virus Shedding (immunology)

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