Abstract | PURPOSE: METHODS: One hundred and twenty-nine eyes were included in this study. Of these, 108 were treated with prostaglandin analogues ( latanoprost, travoprost and bimatoprost), while 21 eyes treated with β-blockers were used as controls. CCT was measured before treatment and at 3-month intervals. RESULTS: A slight but significant increase in CCT was recorded in the bimatoprost and latanoprost groups. Treatment with bimatoprost produced a constant increase (1.85-8.83 μm) in CCT at all time-points of the study. The CCT rise found in the latanoprost group was significant for the first year. Treatment with travoprost did not affect CCT. CONCLUSION: The possibility of corneal thickening under prolonged, local prostaglandin treatment should be investigated further. However, in clinical practice, CCT changes may sometimes influence intraocular pressure measurements significantly.
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Authors | Maria Bafa, Gerasimos Georgopoulos, Constantinos Mihas, Panagiotis Stavrakas, Dimitrios Papaconstantinou, Ioannis Vergados |
Journal | Acta ophthalmologica
(Acta Ophthalmol)
Vol. 89
Issue 5
Pg. 448-51
(Aug 2011)
ISSN: 1755-3768 [Electronic] England |
PMID | 19878123
(Publication Type: Controlled Clinical Trial, Journal Article, Randomized Controlled Trial)
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Copyright | © 2009 The Authors. Journal compilation © 2009 Acta Ophthalmol. |
Chemical References |
- Adrenergic beta-Antagonists
- Amides
- Prostaglandins F, Synthetic
- Prostaglandins, Synthetic
- Cloprostenol
- Latanoprost
- Bimatoprost
- Travoprost
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Topics |
- Adrenergic beta-Antagonists
(administration & dosage)
- Aged
- Amides
(administration & dosage, adverse effects)
- Bimatoprost
- Cloprostenol
(administration & dosage, adverse effects, analogs & derivatives)
- Cornea
(diagnostic imaging, drug effects)
- Female
- Follow-Up Studies
- Glaucoma, Open-Angle
(diagnostic imaging, drug therapy)
- Humans
- Intraocular Pressure
- Latanoprost
- Male
- Middle Aged
- Prostaglandins F, Synthetic
(administration & dosage, adverse effects)
- Prostaglandins, Synthetic
(administration & dosage, adverse effects)
- Travoprost
- Ultrasonography
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