Abstract | OBJECTIVE: METHODS: RESULTS: Median followup times were 3.4 years for the AAV patients and 4.2 years for the CKD patients. More cardiovascular events occurred in the AAV group (23 of 113) than in the CKD group (16 of 113). Cox regression survival analysis showed a significantly increased risk of a cardiovascular event for AAV patients, with a hazard ratio (HR) of 2.23 (95% confidence interval [95% CI] 1.1-4.4) (P = 0.017). Within the cohort of AAV patients, the most strongly predictive factors were previous history of cardiovascular disease (HR 4 [95% CI 1.7-9.8]), history of dialysis dependency (HR 4.3 [95% CI 1.5-12.1]), ever having smoked (HR 3.9 [95% CI 1.5-10]), age at diagnosis (HR 1.038 [95% CI 1.006-1.072]), estimated glomerular filtration rate at remission (HR 0.977 [95% CI 0.957-0.998]), and serum cholesterol concentration at presentation (HR 0.637 [95% CI 0.441-0.92]). CONCLUSION:
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Authors | Matthew D Morgan, Jennifer Turnbull, Umut Selamet, Manvir Kaur-Hayer, Peter Nightingale, Charles J Ferro, Caroline O S Savage, Lorraine Harper |
Journal | Arthritis and rheumatism
(Arthritis Rheum)
Vol. 60
Issue 11
Pg. 3493-500
(Nov 2009)
ISSN: 0004-3591 [Print] United States |
PMID | 19877070
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Acute Coronary Syndrome
(epidemiology)
- Aged
- Angina Pectoris
(epidemiology)
- Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
(complications)
- Chronic Disease
- Cohort Studies
- Female
- Humans
- Incidence
- Ischemic Attack, Transient
(epidemiology)
- Kaplan-Meier Estimate
- Kidney Diseases
(complications)
- Male
- Matched-Pair Analysis
- Middle Aged
- Peripheral Vascular Diseases
(epidemiology)
- Regression Analysis
- Retrospective Studies
- Risk Factors
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