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[Dramatic efficacy of chemotherapy with 5-fluorouracil and dacarbazine in a patient with metastatic glucagonoma and cardiac insufficiency].

Abstract
Malignant glucagonoma is an exceptional pancreatic endocrine tumour, with frequent dermatologic symptoms, diabetes and degradation of the general health status. Prognosis is unfavourable when liver metastases are present due to the usual inefficiency of chemotherapy. We report here an observation of a patient who was treated for a glucagonoma with multiple liver metastases, migratory necrolytic erythema, dilated cardiomypathy and diabetes that dramatically improved after a dacarbazin-based chemotherapy, allowing subsequent surgical resection of the primary. The patient was still alive and asymptomatic without progressive disease nearly two years after surgery.
AuthorsL de Mestier, P Hammel, O Hentic, P Dove, P Lévy, P Ruszniewski
JournalGastroenterologie clinique et biologique (Gastroenterol Clin Biol) Vol. 34 Issue 1 Pg. 106-10 (Jan 2010) ISSN: 0399-8320 [Print] France
Vernacular TitleEfficacité spectaculaire d'une chimiothérapie par 5-fluoro-uracile et dacarbazine chez un malade atteint de glucagonome métastatique avec insuffisance cardiaque.
PMID19875259 (Publication Type: Case Reports, English Abstract, Journal Article)
CopyrightCopyright 2009. Published by Elsevier Masson SAS.
Chemical References
  • Dacarbazine
  • Fluorouracil
Topics
  • Adult
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Cardiomyopathy, Dilated (complications)
  • Dacarbazine (administration & dosage)
  • Female
  • Fluorouracil (administration & dosage)
  • Glucagonoma (drug therapy, pathology, surgery)
  • Humans
  • Liver Neoplasms (drug therapy, secondary)
  • Pancreatic Neoplasms (pathology, surgery)

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