Bimatoprost - a review.

Abstract

Bimatoprost is a synthetic prostamide analog that is efficacious in the treatment of open-angle glaucoma, ocular hypertension and other forms of glaucoma. It reduces intraocular pressure (IOP) by increasing uveoscleral and trabecular outflow. When used as a 0.03% topical preparation once daily, it demonstrates sustained lowering of IOP of 7 - 8 mmHg over a 24-h period. The drug has been found to be more effective than timolol. In some studies it has shown greater ability to lower IOP when compared with other prostaglandin analogs; whereas in others all three clinically used prostaglandin analogs were found to be equally effective. It shows good IOP reduction when used in combination with other glaucoma medications. A common side effect includes mild conjunctival hyperemia, which is generally reversible. Other side effects include periorbital pigmentation, discomfort, ocular surface hyperemia and skin changes. Pharmacoeconomic data indicate that bimatoprost is cost effective in the treatment of open-angle glaucoma.

• Authors: A Jayaprakash Patil, Thasarat S Vajaranant, Deepak P Edward
• Journal: Expert opinion on pharmacotherapy (Expert Opin Pharmacother) Vol. 10 Issue 16 Pg. 2759-68 (Nov 2009) ISSN: 1744-7666 [Electronic] England
• PMID: 19874254 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Amides
• Cloprostenol
• Bimatoprost

Topics

• Amides (adverse effects, pharmacology, therapeutic use)
• Bimatoprost
• Cloprostenol (adverse effects, analogs & derivatives, pharmacology, therapeutic use)
• Glaucoma, Open-Angle (drug therapy, physiopathology)
• Humans
• Intraocular Pressure (drug effects)