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Endolymphatic hydrops and therapeutic effects are visualized in 'atypical' Meniere's disease.

Abstract
A 53-year-old male with fluctuating low frequency sensorineural hearing loss and tinnitus, but without vertigo, was evaluated by MRI obtained by intratympanic injection of a gadolinium-based contrast agent (GBCA) before and after the administration of isosorbide. The endolymphatic hydrops was semi-quantitatively evaluated by a 3.0-T MR scanner. For quantification, the affected side/contralateral side ratios were calculated. A gadodiamide (a kind of GBCA)-enhanced space surrounding the endolymph in the affected side with a 0.50 ratio (which may have represented endolymphatic hydrops) improved after isosorbide therapy to a 0.98 ratio. Thus, endolymphatic hydrops was demonstrated in a patient with 'atypical' Meniere's disease (MD), suggesting that at least some atypical MD may share similar etiology with, and therefore be a continuum of, MD. Also, therapeutic effects could be visualized by using MRI. Therefore, MRI-based diagnosis of MD-related disease will be a powerful tool not only because of its precision but also its usefulness for therapeutic evaluation.
AuthorsMaiko Miyagawa, Hisakuni Fukuoka, Keita Tsukada, Tomohiro Oguchi, Yutaka Takumi, Makoto Sugiura, Hitoshi Ueda, Masumi Kadoya, Shin-ichi Usami
JournalActa oto-laryngologica (Acta Otolaryngol) Vol. 129 Issue 11 Pg. 1326-9 (Nov 2009) ISSN: 1651-2251 [Electronic] England
PMID19863332 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Inflammatory Agents
  • Contrast Media
  • Diuretics, Osmotic
  • gadodiamide
  • Gadolinium DTPA
  • hydrocortisone hemisuccinate
  • Hydrocortisone
  • Isosorbide
Topics
  • Anti-Inflammatory Agents (administration & dosage)
  • Contrast Media (administration & dosage)
  • Diuretics, Osmotic (administration & dosage)
  • Drug Therapy, Combination
  • Endolymph (drug effects)
  • Endolymphatic Hydrops (diagnosis, drug therapy)
  • Gadolinium DTPA
  • Hearing Loss, Sensorineural (etiology)
  • Humans
  • Hydrocortisone (administration & dosage, analogs & derivatives)
  • Image Enhancement
  • Image Processing, Computer-Assisted
  • Isosorbide (administration & dosage)
  • Magnetic Resonance Imaging
  • Male
  • Meniere Disease (diagnosis, drug therapy)
  • Middle Aged
  • Perilymph (drug effects)
  • Tinnitus (etiology)

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