Abstract | AIM: METHODS: From 1990 al 2004 767 patients have been treated and followed, mean follow-up years 6.9+/-2.4. Thirty-two patients Ab-Tg positive after radioiodine ablation, who had showed during the follow-up stable indosable value di Tg, have undergone analysis. RESULTS: The recurrences were statistically more significant when Ab-Tg were increased, than when Ab-Tg were stable or diminished during the time (P<0.0001). Lymphocytic thyroditis was found in thirteen patients (40.6%) at histological specimen after thyroidectomy. The persistence of lymphocytic thyroditis has not modified the value of Ab-Tg as tumor marker (P<0.001). The 10/32 (31.2%) patients Tg negative have been compared to the 61/712 patients Ab-Tg positive (8.6%) who relapse. The recurrence rate was significantly higher for the first group of patients than that for the second (P<0.0001). Multivariate analisys showed N1 (P<0.001; OR 2.51) and Ab-Tg positive (P<0.001; OR: 6.15) associated with recurrences. CONCLUSIONS: Ab-Tg must be determined, in concomitance with Tg, during the follow-up of DTC, to establish the accuracy of Tg, in order to use it as tumour marker. It must be kept in mind that the strongest indication for relapse due to Ab-Tg is an increasing of level in the same patient measured in the long time. Persistent elevated Ab-Tg levels are prognostic of future recurrences.
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Authors | L Pedrazzini, A Baroli, G Lomuscio, L Marzoli |
Journal | Minerva endocrinologica
(Minerva Endocrinol)
Vol. 34
Issue 3
Pg. 195-203
(Sep 2009)
ISSN: 0391-1977 [Print] Italy |
PMID | 19859043
(Publication Type: Journal Article)
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Chemical References |
- Autoantibodies
- Iodine Radioisotopes
- anti-thyroglobulin
- Thyroglobulin
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Autoantibodies
(analysis)
- Carcinoma, Papillary
(radiotherapy, surgery, therapy)
- Carcinoma, Papillary, Follicular
(radiotherapy, surgery, therapy)
- Child
- Child, Preschool
- Combined Modality Therapy
- Female
- Humans
- Iodine Radioisotopes
(therapeutic use)
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(diagnosis)
- Predictive Value of Tests
- Prognosis
- Retrospective Studies
- Thyroglobulin
(immunology)
- Thyroid Neoplasms
(radiotherapy, surgery, therapy)
- Young Adult
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