Abstract | UNLABELLED: PERSPECTIVE: The current study shows that NMDA receptors in supraspinal facilitatory sites maintain noninflammatory muscle pain. Clinical studies in people with chronic widespread, noninflammatory pain, similarly, show alterations in central excitability. Thus, understanding mechanisms in an animal model could lead to improved treatment for patients with chronic muscle pain.
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Authors | Luis F Da Silva, Josimari M Desantana, Kathleen A Sluka |
Journal | The journal of pain
(J Pain)
Vol. 11
Issue 4
Pg. 378-87
(Apr 2010)
ISSN: 1528-8447 [Electronic] United States |
PMID | 19853525
(Publication Type: Journal Article)
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Copyright | Copyright 2010 American Pain Society. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Excitatory Amino Acid Antagonists
- Receptors, N-Methyl-D-Aspartate
- Glutamic Acid
- Sodium Chloride
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Topics |
- Animals
- Disease Models, Animal
- Drug Administration Schedule
- Efferent Pathways
(cytology, physiology)
- Excitatory Amino Acid Antagonists
(pharmacology)
- Glutamic Acid
(metabolism)
- Hyperalgesia
(chemically induced, metabolism, physiopathology)
- Injections, Intramuscular
- Male
- Medulla Oblongata
(cytology, physiology)
- Microinjections
- Muscle, Skeletal
(innervation, physiopathology)
- Muscular Diseases
(chemically induced, metabolism, physiopathology)
- Nociceptors
(drug effects, physiology)
- Pain Measurement
- Pain Threshold
(drug effects, physiology)
- Rats
- Rats, Sprague-Dawley
- Receptors, N-Methyl-D-Aspartate
(metabolism)
- Reticular Formation
(cytology, physiology)
- Sensory Receptor Cells
(drug effects, physiology)
- Sodium Chloride
(adverse effects)
- Synaptic Transmission
(drug effects, physiology)
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