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Successful treatment of immune reconstitution inflammatory syndrome in Whipple's disease using thalidomide.

Abstract
A patient with classic Whipple's disease developed erythema nodosum leprosum-like lesions and fever one month after the beginning of an accurate therapy with trimethoprim-sulfamethoxazole. Immune reconstitution inflammatory syndrome was suspected, but corticosteroid therapy failed to improve the patient. Finally, thalidomide was used and successfully induced rapid improvement.
AuthorsJean-Christophe Lagier, Florence Fenollar, Hubert Lepidi, Eric Liozon, Didier Raoult
JournalThe Journal of infection (J Infect) Vol. 60 Issue 1 Pg. 79-82 (Jan 2010) ISSN: 1532-2742 [Electronic] England
PMID19852981 (Publication Type: Case Reports, Journal Article)
Copyright2009 The British Infection Society. Published by Elsevier Ltd. All rights reserved.
Chemical References
  • Immunosuppressive Agents
  • Thalidomide
  • Trimethoprim, Sulfamethoxazole Drug Combination
Topics
  • Humans
  • Immune Reconstitution Inflammatory Syndrome (drug therapy)
  • Immunosuppressive Agents (therapeutic use)
  • Male
  • Middle Aged
  • Thalidomide (therapeutic use)
  • Treatment Outcome
  • Trimethoprim, Sulfamethoxazole Drug Combination (therapeutic use)
  • Whipple Disease (drug therapy, immunology)

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