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Clofarabine for the treatment of adult acute myeloid leukemia.

Abstract
Clofarabine, a next-generation deoxyadenosine analog, has demonstrated significant activity in patients with acute myeloid leukemia (AML). The single-agent activity compares favorably with that demonstrated by the current standard antileukemia agents. Clofarabine has been safely and effectively combined with other agents and will probably become an integral part of induction and/or consolidation regimens in AML. Current studies are underway to better define the role of clofarabine in younger and elderly patients with AML, and also explore development strategies for an oral formulation.
AuthorsXavier Thomas, Emmanuel Raffoux, Mohamed Elhamri, Ida Lobe, Giovanna Cannas, Hervé Dombret
JournalFuture oncology (London, England) (Future Oncol) Vol. 5 Issue 8 Pg. 1197-210 (Oct 2009) ISSN: 1744-8301 [Electronic] England
PMID19852733 (Publication Type: Journal Article, Review)
Chemical References
  • Adenine Nucleotides
  • Antineoplastic Agents
  • Arabinonucleosides
  • Clofarabine
Topics
  • Adenine Nucleotides (therapeutic use)
  • Adult
  • Aged
  • Animals
  • Antineoplastic Agents (therapeutic use)
  • Arabinonucleosides (therapeutic use)
  • Child
  • Clinical Trials as Topic
  • Clofarabine
  • Humans
  • Leukemia, Myeloid, Acute (drug therapy)

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