Abstract | PURPOSE: The present study was undertaken to clarify the behavioral and electroencephalographic characteristics of olfactory bulb (OB) kindling in rats, in comparison with those of amygdala (AMG) kindling. In addition, the usefulness of OB kindling as a model to evaluate antiepileptics was studied. METHODS: RESULTS: The afterdischarge (AD) threshold of OB kindling is not different from that of AMG kindling. OB-kindled rats showed more rapid development of the seizure stage and AD duration than AMG-kindled rats; however, fully kindled AD duration did not differ between groups. In AMG kindled rats, AD on day 1 was localized only at the stimulation site, whereas in OB-kindled rats, AD on day 1 was observed at not only the stimulation site (OB) but also in the frontal cortex, hippocampus, and AMG. All five antiepileptics significantly inhibited both the seizure stage and AD duration in OB-kindled rats. In addition, carbamazepine, zonisamide, and topiramate were more effective in suppressing OB-kindled seizures. Zonisamide was not effective at any dose tested in AMG-kindled rats. DISCUSSION:
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Authors | Akinori Fujiwara, Yusuke Watanabe, Kenshi Takechi, Takashi Ishikawa, Yuko Kaida, Masaaki Akagi, Chiaki Kamei |
Journal | Epilepsia
(Epilepsia)
Vol. 51
Issue 3
Pg. 445-53
(Mar 2010)
ISSN: 1528-1167 [Electronic] United States |
PMID | 19845738
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Anticonvulsants
- Isoxazoles
- Carbamazepine
- Zonisamide
- Valproic Acid
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Topics |
- Amygdala
(drug effects, physiopathology)
- Animals
- Anticonvulsants
(pharmacology)
- Behavior, Animal
(physiology)
- Carbamazepine
(pharmacology)
- Disease Models, Animal
- Electric Stimulation
(methods)
- Electrodes, Implanted
- Electroencephalography
(drug effects, statistics & numerical data)
- Epilepsy, Complex Partial
(physiopathology, prevention & control)
- Epilepsy, Generalized
(physiopathology, prevention & control)
- Frontal Lobe
(drug effects, physiopathology)
- Hippocampus
(drug effects, physiopathology)
- Isoxazoles
(pharmacology)
- Kindling, Neurologic
- Male
- Olfactory Bulb
(drug effects, physiopathology)
- Rats
- Rats, Wistar
- Seizures
(etiology, physiopathology, prevention & control)
- Valproic Acid
(pharmacology)
- Zonisamide
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