Abstract | BACKGROUND: OBJECTIVE AND METHODS: RESULTS: 1170 patients were selected for analysis. After 24 months of treatment, BP control (Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure VI criteria) was 82.1% and 82.6% in the verapamil sustained release (SR) + trandolapril (Ve + Tr) and atenolol + hydrochlorothiazide (At + HCTZ) groups, respectively (p = 0.86). In Ve + Tr compared to At + HCTZ patients, adjusted risk for PO (hazard ratio [HR] 0.63; 95% CI 0.37, 1.05; p = 0.07) and unadjusted risks for secondary outcomes including death (HR 0.70; 95% CI 0.40, 1.25), total MI (HR 0.82; 95% CI 0.35, 1.90), total stroke (HR 0.81; 95% CI 0.25, 2.65) and new diabetes (HR 0.88; 95% CI 0.55, 1.41) were not statistically different. CONCLUSION: This analysis shows that combination treatment with either Ve+ Tr or At +- HCTZ is effective in achieving BP control and produces similar outcomes in hypertensive patients with CAD.
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Authors | George L Bakris, Rhonda M Cooper-Dehoff, Qian Zhou, Stuart Kupfer, Annette Champion, Carl J Pepine, INVEST Investigators |
Journal | American journal of cardiovascular drugs : drugs, devices, and other interventions
(Am J Cardiovasc Drugs)
Vol. 7 Suppl 1
Pg. 25-9
( 2007)
ISSN: 1175-3277 [Print] New Zealand |
PMID | 19845074
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Adrenergic beta-Antagonists
- Angiotensin-Converting Enzyme Inhibitors
- Antihypertensive Agents
- Calcium Channel Blockers
- Diuretics
- Indoles
- Hydrochlorothiazide
- trandolapril
- Atenolol
- Verapamil
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Topics |
- Adrenergic beta-Antagonists
(therapeutic use)
- Aged
- Analysis of Variance
- Angiotensin-Converting Enzyme Inhibitors
(therapeutic use)
- Antihypertensive Agents
(therapeutic use)
- Atenolol
(therapeutic use)
- Blood Pressure
(drug effects)
- Calcium Channel Blockers
(therapeutic use)
- Coronary Artery Disease
(complications)
- Diuretics
(therapeutic use)
- Drug Therapy, Combination
- Female
- Humans
- Hydrochlorothiazide
(therapeutic use)
- Hypertension
(complications, drug therapy)
- Indoles
(therapeutic use)
- Male
- Middle Aged
- Proportional Hazards Models
- Retrospective Studies
- Treatment Outcome
- Verapamil
(therapeutic use)
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