[A case of unresectable hilar bile duct cancer responding to chemo-radiotherapy by gemcitabine].

Abstract

A 66-year-old woman was admitted to our hospital because of general fatigue and icterus. PTC findings showed irregular stenosis of hilar bile duct. Abdominal CT scan showed a dilatation of the intra-hepatic bile duct and a tumor around hilar bile duct. We diagnosed it as hilar bile duct carcinoma, and although we operated it was unresectable because of the metastasis of a para-aorta lymph node and duodenal invasion. We started chemo-radiotherapy with a total dose of 45 Gy and gemcitabine. The tumor and para-aorta lymph node were remarkably decreased, and tumor marker CA 19-9 was also decreased to within the normal range. The patient had a peritoneal dissemination 10 months after the chemo-radiotherapy and survived 20 months.

• Authors: Naohiko Kohya, Kazuyoshi Hashiguchi, Tomomi Yakabe, Atsushi Miyoshi, Takao Ohtsuka, Kenji Kitahara, Kohji Miyazaki
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 36 Issue 10 Pg. 1753-5 (Oct 2009) ISSN: 0385-0684 [Print] Japan
• PMID: 19838042 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antimetabolites, Antineoplastic
• Biomarkers, Tumor
• Deoxycytidine
• Gemcitabine

Topics

• Aged
• Antimetabolites, Antineoplastic (therapeutic use)
• Bile Duct Neoplasms (diagnostic imaging, drug therapy, radiotherapy, surgery)
• Biomarkers, Tumor (blood)
• Combined Modality Therapy
• Deoxycytidine (analogs & derivatives, therapeutic use)
• Duodenal Neoplasms (diagnostic imaging, drug therapy, secondary)
• Fatal Outcome
• Female
• Humans
• Lymphatic Metastasis
• Neoplasm Invasiveness
• Radiography
• Gemcitabine