Abstract | OBJECTIVE: The aim of this study was to analyze the antithrombin-III (AT-III) activity in the serum in relation to other laboratory findings, including the serum albumin, total protein (TP), and uric acid (UA), and to assess the recovery of the AT-III activity in the serum after its administration in obstetrically ill patients. PATIENTS AND METHODS: The medical records of 27 patients who were diagnosed to have disseminated intravascular coagulation ( DIC) based on the obstetric DIC scores were reviewed and the relationships between the activity of AT-III in the serum and other laboratory findings were evaluated. The effect of administration of AT-III on the recovery of AT-III activity in the serum was also evaluated. RESULTS: All the patients survived without any sequelae. The mean obstetric DIC score was 11.1 ± 3.1 (range 8-19) and the mean blood loss during the first 24 hours was 3798 ± 3,435 mL (range 480-16 208 mL). There was a significant correlation between the serum AT-III activity before the treatment and the serum albumin (r = .67, P = .001) and TP (r = .59, P = .021), but not serum UA. Seven patients required over 3000 IU of AT-III concentrate to obtain an increase in the serum AT-III activity to over 70%. The UA level in this group was significantly higher than that in the remaining patients. CONCLUSION: The serum AT-III activity was correlated with the serum albumin level before the start of treatment. Therefore, measurement of the serum albumin level before and during treatment is helpful.
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Authors | Aiko Kobayashi, Yoshio Matsuda, Minoru Mitani, Yasuo Makino, Hiroaki Ohta |
Journal | Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
(Clin Appl Thromb Hemost)
Vol. 16
Issue 6
Pg. 688-93
(Dec 2010)
ISSN: 1938-2723 [Electronic] United States |
PMID | 19833617
(Publication Type: Journal Article)
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Chemical References |
- Blood Proteins
- Serum Albumin
- Uric Acid
- Antithrombin III
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Topics |
- Adult
- Antithrombin III
(metabolism, therapeutic use)
- Blood Proteins
(metabolism)
- Disseminated Intravascular Coagulation
(blood, drug therapy)
- Female
- Humans
- Serum Albumin
(metabolism)
- Uric Acid
(blood)
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