Abstract | AIM: METHODS: We retrospectively collected serum samples before and 3, 6, 9 and 12 months postpartum from 58 PPT patients. Levels of TPOAb and its IgG subtypes were examined by ELISA. RESULTS: Titers of total TPOAb and its IgG subtypes were lowest before delivery in PPT patients. Following delivery, titers of total TPOAb increased. Concentrations of IgG1 and IgG4 subtypes increased for 3 months postpartum, then became stable. Concentrations of the IgG2 subtype increased gradually until 9 months postpartum. Concentrations of the IgG3 subtype reached a peak at 6 months postpartum and remained at a high level thereafter. In PPT patients with an episode of hypothyroidism, levels of total TPOAb and of the IgG subtypes as well as the IgG1/ IgG4 ratios were significantly higher than those in patients with an episode of hyperthyroidism and normal controls. Correlations between titers of TPOAb and thyroid-stimulating hormone levels (positive) and free T(4) levels (negative) were seen 6 months postpartum. CONCLUSION: TPOAb is related to thyroid injury and the IgG1 subtype of TPOAb may play a major role in the damage of the thyroid in PPT.
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Authors | Di Teng, Chenyang Li, Ying Teng, Yuhong Ouyang, Yushu Li, Weiping Teng |
Journal | Gynecologic and obstetric investigation
(Gynecol Obstet Invest)
Vol. 69
Issue 1
Pg. 24-9
( 2010)
ISSN: 1423-002X [Electronic] Switzerland |
PMID | 19829002
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2009 S. Karger AG, Basel. |
Chemical References |
- Immunoglobulin Isotypes
- Iodide Peroxidase
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Topics |
- China
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Immunoglobulin Isotypes
(blood, immunology)
- Iodide Peroxidase
(blood, immunology)
- Postpartum Period
- Postpartum Thyroiditis
(enzymology, immunology)
- Retrospective Studies
- Statistics, Nonparametric
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