[Treatment of patients with arterial hypertension and other stroke risk factors in clinical practice. The PROGNOS program].

Abstract

AIM:

To analyse recent data on the treatment of arterial hypertension (AH) with other risk factors (RF) of cerebral stroke in the Russian Federation, assessment of effects of antihypertensive treatment with a combined drug Hyzaar on the risk of cardiovascular complications (including cerebral stroke), on affection of target organs and metabolic factors of atherosclerosis.

MATERIAL AND METHODS:

A total of 500 outpatients with primary AH and risk factors including the risk of stroke received Hyzaar (losartan 50/100 mg and hydrochlorthiaside 12.5/25 mg) for one year.

RESULTS:

More frequent RF in hypertensive patients are the following: high blood cholesterol (86.7%), left ventricular hypertrophy (53.2%), familial history of AH (74.2%). A combination of three and two RF occurs in 49.1 and 37% hypertensive patients, respectively. A 6-month treatment with Hyzaar lowered systolic blood pressure by 28.4 mm Hg and diastolic one by 15.4 mm Hg. The target blood pressure was achieved in 83.5%. Real clinical practice showed that administration of a target Hyzaar dose for 6 months leads to a 6.5% regress of left ventricular hypertrophy, an 11% decrease of total cholesterol, a 4% decrease of glucose and a 8.9% decrease of uric acid.

CONCLUSION:

A control of AH and correction of RF in hypertensive patients with a high RF of stroke and other cardiovascular complications is real in use of adequate antihypertensive therapy.

• Authors: M G Bubnova, R G Oganov
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 81 Issue 9 Pg. 19-23 ( 2009) ISSN: 0040-3660 [Print] Russia (Federation)
• PMID: 19827647 (Publication Type: English Abstract, Journal Article)

Chemical References

• Drug Combinations
• hydrochlorothiazide, losartan drug combination
• Hydrochlorothiazide
• Losartan

Topics

• Aged
• Drug Combinations
• Female
• Humans
• Hydrochlorothiazide (administration & dosage, therapeutic use)
• Hypertension (blood, complications, drug therapy)
• Losartan (administration & dosage, therapeutic use)
• Male
• Middle Aged
• Risk Factors
• Stroke (etiology, prevention & control)