Abstract | OBJECTIVES: The aim of the present experimental study was to evaluate the effect of prebiotic on chemically induced carcinogenensis in rats fed with high fat diet (HF). METHODS: Wistar albino rats were divided into control and experimental groups. In experimental group rats were treated with prebiotic at the dose of 2% of HF diet. N,N-dimethylhydrazine ( DMH) injections were applicated in dose 20 mg/kg b.w., two times at week interval. In the end of eight weeks experimental period blood samples and feaces were taken from the rats and used for laboratory analysis. RESULTS: CONCLUSION:
Prebiotics may have potential health implications for protection against colon cancer (Tab. 2, Fig. 1, Ref. 14).
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Authors | E Hijova, A Chmelarova, A Bomba, R Zitnan |
Journal | Bratislavske lekarske listy
(Bratisl Lek Listy)
Vol. 110
Issue 9
Pg. 523-5
( 2009)
ISSN: 0006-9248 [Print] Slovakia |
PMID | 19827333
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Bacteria
(enzymology)
- Colonic Neoplasms
(chemically induced, prevention & control)
- Feces
(microbiology)
- Inulin
(therapeutic use)
- Probiotics
(therapeutic use)
- Rats
- Rats, Wistar
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