Abstract | BACKGROUND: OBJECTIVES: SEARCH STRATEGY: We searched Cochrane CENTRAL, MEDLINE, EMBASE and the Oxford Pain Relief Database for studies to June 2009. SELECTION CRITERIA: DATA COLLECTION AND ANALYSIS: Two review authors independently assessed trial quality and extracted data. We planned to use area under the " pain relief versus time" curve to derive the proportion of participants with tiaprofenic acid experiencing at least 50% pain relief over 4 to 6 hours, using validated equations; to use number needed to treat to benefit (NNT); the proportion of participants using rescue analgesia over a specified time period; time to use of rescue analgesia; information on adverse events and withdrawals. MAIN RESULTS: Not one of eleven studies identified by the searches and examined in detail studied oral tiaprofenic acid against placebo in patients with established postoperative pain and therefore no results are available. AUTHORS' CONCLUSIONS: In the absence of evidence of efficacy for oral tiaprofenic acid in acute postoperative pain, its use in this indication is not justified at present. Because trials clearly demonstrating analgesic efficacy in the most basic of acute pain studies is lacking, use in other indications should be evaluated carefully. Given the large number of available drugs of this and similar classes which are effective, there is no urgent research agenda for this particular drug.
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Authors | R Andrew Moore, Sheena Derry, Maura Moore, Henry J McQuay |
Journal | The Cochrane database of systematic reviews
(Cochrane Database Syst Rev)
Issue 4
Pg. CD007542
(Oct 07 2009)
ISSN: 1469-493X [Electronic] England |
PMID | 19821426
(Publication Type: Journal Article, Review, Systematic Review)
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Chemical References |
- Analgesics
- Anti-Inflammatory Agents, Non-Steroidal
- Propionates
- tiaprofenic acid
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Topics |
- Acute Disease
- Administration, Oral
- Adult
- Analgesics
(administration & dosage)
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage)
- Humans
- Pain, Postoperative
(drug therapy)
- Propionates
(administration & dosage)
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