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A typhus group-specific protease defies reductive evolution in rickettsiae.

Abstract
Phylogenomics reveals extreme gene loss in typhus group (TG) rickettsiae relative to the levels for other rickettsial lineages. We report here a curious protease-encoding gene (ppcE) that is conserved only in TG rickettsiae. As a possible determinant of host pathogenicity, ppcE warrants consideration in the development of therapeutics against epidemic and murine typhus.
AuthorsNicole C Ammerman, Joseph J Gillespie, Andrew F Neuwald, Bruno W Sobral, Abdu F Azad
JournalJournal of bacteriology (J Bacteriol) Vol. 191 Issue 24 Pg. 7609-13 (Dec 2009) ISSN: 1098-5530 [Electronic] United States
PMID19820087 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
Chemical References
  • Bacterial Proteins
  • Serine Endopeptidases
  • group-specific protease
Topics
  • Amino Acid Sequence
  • Bacterial Proteins (genetics)
  • Conserved Sequence
  • Evolution, Molecular
  • Models, Molecular
  • Molecular Sequence Data
  • Phylogeny
  • Protein Structure, Tertiary
  • Rickettsieae (enzymology, genetics)
  • Sequence Alignment
  • Serine Endopeptidases (genetics)

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