Abstract |
Phylogenomics reveals extreme gene loss in typhus group (TG) rickettsiae relative to the levels for other rickettsial lineages. We report here a curious protease-encoding gene (ppcE) that is conserved only in TG rickettsiae. As a possible determinant of host pathogenicity, ppcE warrants consideration in the development of therapeutics against epidemic and murine typhus.
|
Authors | Nicole C Ammerman, Joseph J Gillespie, Andrew F Neuwald, Bruno W Sobral, Abdu F Azad |
Journal | Journal of bacteriology
(J Bacteriol)
Vol. 191
Issue 24
Pg. 7609-13
(Dec 2009)
ISSN: 1098-5530 [Electronic] United States |
PMID | 19820087
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
|
Chemical References |
- Bacterial Proteins
- Serine Endopeptidases
- group-specific protease
|
Topics |
- Amino Acid Sequence
- Bacterial Proteins
(genetics)
- Conserved Sequence
- Evolution, Molecular
- Models, Molecular
- Molecular Sequence Data
- Phylogeny
- Protein Structure, Tertiary
- Rickettsieae
(enzymology, genetics)
- Sequence Alignment
- Serine Endopeptidases
(genetics)
|