Abstract | OBJECTIVE: METHODS: The prospective, randomized, open-label, blinded end-point design of study was used. One hundred and ten patients having PCPP lasting three months or more were randomized to receive 800 mg/daily gabapentin (n=55) and 75 mg/daily diclofenac (n=55) for thirty days. All patients have undergone cardiac surgery and median sternotomy. The perception of pain or paresthesia was evaluated as 0--Normal (no pain or paresthesia), 1--Mild, 2--Moderate, 3--Severe at baseline and after thirty days of treatment. Recurrences were questioned after three months. Statistical analyses were performed using independent samples t, Chi-square, continuity correction, Fisher's exact, Mann Whitney U and Kruskal Wallis tests. RESULTS: In gabapentin group, mean pain and paresthesia scores regressed from 2.12+/- 0.76 to 0.54+/- 0.83 (p<0.001) and from 1.72+/- 0.74 to 0.49+/- 0.62 (p<0.001), respectively. Mean pain and paresthesia scores regressed in diclofenac group from 1.93+/- 0.8 to 1.0+/- 1.13 (p<0.001) and from 1.76+/- 0.74 to 1.24+/- 0.96 (p=0.002), respectively. Although, both gabapentin and diclofenac were found to be effective without obvious side effects in the treatment of PCPP (p<0.001), gabapentin was found to be superior to diclofenac (p=0.001 and p<0.001, respectively). Adverse effects were seen in 7% of patients on gabapentin and 4% of patients on diclofenac. Results also showed that symptomatic relief with gabapentin lasts longer than diclofenac (p<0.001). CONCLUSION:
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Authors | Ismail Biyik, Metin Gülcüler, Murat Karabiga, Oktay Ergene, Nezih Tayyar |
Journal | Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology
(Anadolu Kardiyol Derg)
Vol. 9
Issue 5
Pg. 390-6
(Oct 2009)
ISSN: 1308-0032 [Electronic] Turkey |
PMID | 19819790
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Amines
- Analgesics
- Anti-Inflammatory Agents, Non-Steroidal
- Cyclohexanecarboxylic Acids
- Diclofenac
- gamma-Aminobutyric Acid
- Gabapentin
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Amines
(therapeutic use)
- Analgesics
(therapeutic use)
- Anti-Inflammatory Agents, Non-Steroidal
(therapeutic use)
- Chest Pain
(drug therapy, etiology)
- Cyclohexanecarboxylic Acids
(therapeutic use)
- Diclofenac
(therapeutic use)
- Female
- Gabapentin
- Humans
- Male
- Middle Aged
- Paresthesia
(drug therapy, etiology)
- Severity of Illness Index
- Sternotomy
(adverse effects)
- Treatment Outcome
- gamma-Aminobutyric Acid
(therapeutic use)
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