Abstract | OBJECTIVES: METHODS: We performed a randomized, double-blind, controlled trial in 99 children. MgSO(4) or placebo was administered during the rewarming phase of cardiopulmonary bypass: group 1, placebo group (29 patients); group 2, 25 mg/kg of MgSO(4) (30 patients); and group 3, 50 mg/kg of MgSO(4) (40 patients). RESULTS: At the time of admission to the cardiac intensive care unit, groups receiving MgSO(4) had significantly greater levels of ionized magnesium (group 1, 0.51 + or - 0.07; group 2, 0.57 + or - 0.09; group 3, 0.59 + or - 0.09). Hypomagnesemia before bypass was common (75%-86.2%) and not significantly different among the groups. The proportion of hypomagnesemia decreased significantly at admission to the cardiac intensive care unit in groups receiving MgSO(4) (group 1, 77.8%; group 2, 63%; group 3, 47.4%). Patients receiving placebo (group 1) had a significantly greater occurrence of junctional ectopic tachycardia than groups receiving MgSO(4) (group 1, n = 5 [17.9%]; group 2, n = 2 [6.7%]; group 3, n = 0 [0%]). Age (<1 month), Aristotle score (>4), and history of cardiac failure were associated with junctional ectopic tachycardia. None of the patients with those characteristics in group 3 had junctional ectopic tachycardia. No association was found between study groups and the Pediatric Risk of Mortality score or length of stay in the cardiac intensive care unit. CONCLUSIONS:
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Authors | Ana M Manrique, Margarita Arroyo, Yan Lin, Samar R El Khoudary, Erin Colvin, Steven Lichtenstein, Constantinos Chrysostomou, Richard Orr, Edmund Jooste, Peter Davis, Peter Wearden, Victor Morell, Ricardo Munoz |
Journal | The Journal of thoracic and cardiovascular surgery
(J Thorac Cardiovasc Surg)
Vol. 139
Issue 1
Pg. 162-169.e2
(Jan 2010)
ISSN: 1097-685X [Electronic] United States |
PMID | 19819469
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2010 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved. |
Chemical References |
- Anti-Arrhythmia Agents
- Magnesium Sulfate
- Magnesium
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Topics |
- Adolescent
- Anti-Arrhythmia Agents
(administration & dosage, therapeutic use)
- Cardiopulmonary Bypass
- Child
- Child, Preschool
- Double-Blind Method
- Female
- Humans
- Infant
- Infant, Newborn
- Magnesium
(blood)
- Magnesium Sulfate
(administration & dosage, therapeutic use)
- Male
- Postoperative Complications
(prevention & control)
- Tachycardia, Ectopic Junctional
(prevention & control)
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