Escin has been used extensively to treat chronic
venous insufficiency,
hemorrhoids, and
edema resulting from cerebral ischemic damage,
trauma or operation. However, no studies have looked at the anti-inflammatory properties of
escin administered by
intravenous injection, and it is still not clear whether
escin has an effect on the immune system. This study seeks to investigate the time-dependent anti-inflammatory properties of
escin and its effect on the immune system. The anti-inflammatory effect of
escin was observed in
carrageenan-induced paw
edema and
acetic acid-induced capillary permeability in mice. The immunopharmacological effects of
escin were evaluated by spleen index (SI), thymus index (TI), proliferative capacity of splenocytes (PS), lymphocyte count (LC), serum
TNF-alpha levels, and phagocytic rate (PR) in mice.
Escin treatment showed a significant anti-inflammatory effect, similar to that seen with
dexamethasone treatment. However, the duration of the anti-inflammatory response was longer with
escin treatment than with
dexamethasone treatment. The results also demonstrated that
escin had no significant effects on SI, TI, LC, PS,
TNF-alpha levels, and PR. The findings suggest that
escin is a potent anti-inflammatory
drug with long-lasting anti-inflammatory effects and without any immunosuppressive effects.