Lipid profile as a prognostic factor in cancer patients.

Abstract

PURPOSE:

The relationship between plasma lipid levels and neoplastic diseases is still unclear. The aim of this study was to analyse the lipid profile of individuals with non-Hodgkin's lymphoma (NHL) or prostate carcinoma (CaP) and to follow serum lipid levels changes in NHL patients according to their response to chemotherapy.

PATIENTS AND METHODS:

Forty-seven patients with NHL, 57 patients with CaP, two control groups composed of 29 and 43 age- and sex-matched healthy adults, related to NHL and CaP patients, respectively, were included in the study. Follow-up studies of NHL patients were carried out after the 3rd and 6th cycle of chemotherapy.

RESULTS:

Initial plasma cholesterol (Chol), HDL-cholesterol (HDL-Chol) and phospholipids (PL) values were significantly lower in patients with NHL or CaP than in controls. Following chemotherapy, we noticed a progressive increase in lipid levels in NHL patients with complete remission (CR) and stable disease (SD), and further decrease in patients with the disease progression.

CONCLUSION:

Decreased plasma Chol, HDL-Chol and PL levels of patients with NHL or CaP can be considered as non-specific prognostic parameters in patients with these malignancies.

• Authors: Z Cvetkovic, B Cvetkovic, M Petrovic, M Ranic, J Debeljak-Martarcic, V Vucic, M Glibetic
• Journal: Journal of B.U.ON. : official journal of the Balkan Union of Oncology (J BUON) 2009 Jul-Sep Vol. 14 Issue 3 Pg. 501-6 ISSN: 1107-0625 [Print] Cyprus
• PMID: 19810145 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cholesterol, HDL
• Lipids
• Phospholipids
• Triglycerides
• Cholesterol

Topics

• Adult
• Aged
• Carcinoma (blood)
• Cholesterol (blood)
• Cholesterol, HDL (blood)
• Female
• Humans
• Lipids (blood)
• Lymphoma, Non-Hodgkin (blood)
• Male
• Middle Aged
• Phospholipids (blood)
• Prognosis
• Prostatic Neoplasms (blood)
• Triglycerides (blood)