Subcutaneous versus intramuscular depot methoxyprogesterone acetate: a comparative review.

Abstract

Depot medroxyprogesterone acetate (DMPA; Depo-Provera) is a highly effective and convenient contraceptive method that has been used worldwide for many decades. Recently, a new lower dose of DMPA, administered as a subcutaneous injection, has been approved for use in the USA as a contraceptive and a treatment for pain associated with endometriosis. The newer formulation has a similar efficacy to the older version and, more importantly, has fewer side effects, with improved user tolerability. Similar to the intramuscular DMPA injection (Depo-Provera intramuscular or contraceptive injection), the subcutaneous injection provides effective contraceptive and pain-management therapy for endometriosis, with a 3-monthly injectable protocol for women who seek long-term and reversible contraception without the need for a daily pill or a more frequent dosing regimen.

• Authors: Melissa A Simon, Lee P Shulman
• Journal: Women's health (London, England) (Womens Health (Lond)) Vol. 2 Issue 2 Pg. 191-7 (Mar 2006) ISSN: 1745-5065 [Electronic] United States
• PMID: 19803889 (Publication Type: Journal Article)