A case of malignant pheochromocytoma treated with 131I-metaiodobenzylguanidine and alpha-methyl-p-tyrosine.

Abstract

A 47-year-old man had surgery for paraaortic paraganglioma in 1980 and 1985. In 1987, his urinary excretion of catecholamines and metabolites was extremely high. Scintigraphy with 131I-metaiodobenzylguanidine (MIBG) showed multiple bone and liver metastases. He was treated twice with infusions of 3.7 GBq of 131I-MIBG. After the first treatment, he had transient hypertension and pain in the back and right leg. Subsequent 131I-MIBG scintigraphy showed that the number of metastatic tumors had decreased. The second treatment was less effective. Excess catecholamines were treated with alpha-methyl-p-tyrosine (MPT), a catecholamine synthesis inhibitor, at doses between 250 and 2000 mg/day, which significantly decreased urinary NE excretion. This is the first case treated with 131I-MIBG in Japan.

• Authors: Y Nakagami, K Nomura, K Kusakabe, N Miko, T Tsushima, H Demura
• Journal: Japanese journal of medicine (Jpn J Med) 1990 May-Jun Vol. 29 Issue 3 Pg. 329-33 ISSN: 0021-5120 [Print] Japan
• PMID: 1980321 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Iodine Radioisotopes
• Iodobenzenes
• Methyltyrosines
• Normetanephrine
• 3-Iodobenzylguanidine
• Metanephrine
• Vanilmandelic Acid
• alpha-Methyltyrosine
• Tyrosine 3-Monooxygenase
• Norepinephrine
• Epinephrine

Topics

• 3-Iodobenzylguanidine
• Adrenal Gland Neoplasms (diagnosis, drug therapy, metabolism)
• Antineoplastic Agents (therapeutic use)
• Blood Chemical Analysis
• Epinephrine (metabolism)
• Humans
• Iodine Radioisotopes (therapeutic use)
• Iodobenzenes (therapeutic use)
• Male
• Metanephrine (metabolism)
• Methyltyrosines (therapeutic use)
• Middle Aged
• Norepinephrine (metabolism)
• Normetanephrine (metabolism)
• Pheochromocytoma (diagnosis, drug therapy, metabolism)
• Radionuclide Imaging
• Tyrosine 3-Monooxygenase (administration & dosage)
• Vanilmandelic Acid (metabolism)
• alpha-Methyltyrosine