Abstract | INTRODUCTION: METHODS: Fifty-four root canals were selected. Samples were collect before (s1) and after chemomechanical preparation (s2). Teeth were randomly divided into groups: GI, 2.5% NaOCl (n = 27) and GII, CHX gel (n = 27). Limulus amebocyte lysate assay was used to quantify endotoxins. RESULTS:
Endotoxin was present in 100% of the samples investigated, with a median value of 272 endotoxin units (EU)/mL (GI) and of 152.46 EU/mL (GII). As a result of chemomechanical preparation, LPS content was reduced to a median value of 86 EU/mL (GI) and 85 EU/mL (GII). Higher percentage value of endotoxin reduction was found in GI (P < .05). CONCLUSIONS: The 2.5% NaOCl and 2% CHX gel were not effective in eliminating endotoxin from the primarily infected root canals.
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Authors | Brenda P F A Gomes, Frederico C Martinho, Morgana E Vianna |
Journal | Journal of endodontics
(J Endod)
Vol. 35
Issue 10
Pg. 1350-3
(Oct 2009)
ISSN: 1878-3554 [Electronic] United States |
PMID | 19801228
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Infective Agents, Local
- Chromogenic Compounds
- Endotoxins
- Lipopolysaccharides
- Root Canal Irrigants
- Sodium Hypochlorite
- Chlorhexidine
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Topics |
- Adolescent
- Adult
- Anti-Infective Agents, Local
(therapeutic use)
- Chlorhexidine
(therapeutic use)
- Chromogenic Compounds
- Dental Pulp Cavity
(drug effects, microbiology)
- Dental Pulp Necrosis
(microbiology, therapy)
- Endotoxins
(analysis)
- Humans
- Lipopolysaccharides
(analysis)
- Middle Aged
- Periapical Periodontitis
(microbiology, therapy)
- Root Canal Irrigants
(therapeutic use)
- Root Canal Preparation
(methods)
- Sodium Hypochlorite
(therapeutic use)
- Treatment Outcome
- Young Adult
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