Postoperative concurrent nedaplatin-based chemoradiotherapy improves survival in early-stage cervical cancer patients with adverse risk factors.

The aim of this study was to evaluate the efficacy of postoperative nedaplatin-based concurrent chemoradiotherapy (CCRT) in patients with FIGO stage IA2-IIB cervical cancer with adverse risk factors.
We retrospectively reviewed the medical records of 183 patients with early-stage cervical cancer who had undergone radical surgery between April 1997 and March 2006. Of these, 68 patients displayed high-risk prognostic factors such as positive pelvic lymph nodes, parametrial involvement, or a positive surgical margin. Fifty-seven patients demonstrated intermediate-risk prognostic factors including deep stromal invasion, capillary lymphatic space involvement, or large tumor diameter. These patients were treated postoperatively with CCRT or radiotherapy alone (RT). Fifty-eight patients showed no risk factors and, therefore, received no adjuvant therapy after surgery. The 3-year recurrence rate, progression free survival (PFS), and overall survival (OS) were compared between the treatment groups.
CCRT was significantly superior to RT alone with regard to recurrence rate, PFS, and OS in patients that displayed high-risk and intermediate-risk prognostic factors. The frequencies of acute grade 3-4 toxicities were significantly higher in patients treated with CCRT than in those treated with RT alone. However, no statistically significant difference was observed with regard to severe late toxicities.
Postoperative nedaplatin-based CCRT was safely performed and improved the prognosis of FIGO stage IA2-IIB cervical cancer patients displaying high-risk or intermediate-risk prognostic factors. This treatment can be considered as an alternative to cisplatin-based chemoradiotherapy in this patient population.
AuthorsSeiji Mabuchi, Ken-ichirou Morishige, Fumiaki Isohashi, Yasuo Yoshioka, Takashi Takeda, Toshiya Yamamoto, Kiyoshi Yoshino, Takayuki Enomoto, Takehiro Inoue, Tadashi Kimura
JournalGynecologic oncology (Gynecol Oncol) Vol. 115 Issue 3 Pg. 482-7 (Dec 2009) ISSN: 1095-6859 [Electronic] United States
PMID19783286 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Organoplatinum Compounds
  • nedaplatin
  • Adult
  • Antineoplastic Agents (adverse effects, therapeutic use)
  • Chemotherapy, Adjuvant
  • Female
  • Humans
  • Middle Aged
  • Neoplasm Staging
  • Organoplatinum Compounds (adverse effects, therapeutic use)
  • Prognosis
  • Radiotherapy, Adjuvant
  • Retrospective Studies
  • Risk Factors
  • Treatment Outcome
  • Uterine Cervical Neoplasms (pathology, therapy)

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