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Effects of dapiprazole on the reversal of pharmacologically induced mydriasis.

Abstract
The ability of a new alpha-adrenergic antagonist, dapiprazole, to reverse mydriasis produced by phenylephrine 2.5% or 10%, tropicamide 0.5%, and the combination of phenylephrine 2.5% and tropicamide 0.5% was investigated. A double masked crossover design was used to study both efficacy of mydriatic reversal and time course. The safety of administration was evaluated as well. Subjects were optometry students and their spouses. The results demonstrate that dapiprazole is safe and effective for reversing mydriasis produced by both concentrations of phenylephrine, and partially effective in reversing mydriasis in eyes treated with tropicamide 0.5%, alone, or in combination with 2.5% phenylephrine.
AuthorsN Nyman, E U Keates
JournalOptometry and vision science : official publication of the American Academy of Optometry (Optom Vis Sci) Vol. 67 Issue 9 Pg. 705-9 (Sep 1990) ISSN: 1040-5488 [Print] United States
PMID1978275 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Adrenergic alpha-Antagonists
  • Mydriatics
  • Piperazines
  • Triazoles
  • Phenylephrine
  • dapiprazole
  • Tropicamide
Topics
  • Accommodation, Ocular (drug effects)
  • Adrenergic alpha-Antagonists (pharmacology)
  • Adult
  • Blood Pressure (drug effects)
  • Double-Blind Method
  • Female
  • Humans
  • Intraocular Pressure (drug effects)
  • Male
  • Mydriatics (antagonists & inhibitors)
  • Phenylephrine (antagonists & inhibitors)
  • Piperazines
  • Pupil (drug effects)
  • Time Factors
  • Triazoles (pharmacology, toxicity)
  • Tropicamide (antagonists & inhibitors)
  • Visual Acuity (drug effects)

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