Abstract | BACKGROUND/AIMS: METHODS: PC-Pkd1-KO mice, which have homozygous mutations of the Pkd1 gene in principal cells, were used. On the day after giving birth, mothers were fed standard mouse chow with or without pioglitazone (30 mg/kg chow). After weaning, the assigned diet was continued. At 1 month of age, blood pressure was measured and animals were sacrificed to determine kidney weight, body weight, and serum urea. Kidneys were evaluated for proliferation using Ki-67, apoptosis using TUNEL analysis, and cyst number using MRI. Survival was observed. RESULTS: CONCLUSION:
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Authors | K L Raphael, K A Strait, P K Stricklett, B C Baird, K Piontek, G G Germino, D E Kohan |
Journal | American journal of nephrology
(Am J Nephrol)
Vol. 30
Issue 5
Pg. 468-73
( 2009)
ISSN: 1421-9670 [Electronic] Switzerland |
PMID | 19776560
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2009 S. Karger AG, Basel. |
Chemical References |
- Hypoglycemic Agents
- TRPP Cation Channels
- Thiazolidinediones
- polycystic kidney disease 1 protein
- Pioglitazone
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Topics |
- Animals
- Blood Pressure
(drug effects)
- Disease Models, Animal
- Hypertension, Renal
(drug therapy, mortality, pathology)
- Hypoglycemic Agents
(pharmacology)
- Kaplan-Meier Estimate
- Kidney
(drug effects, pathology, physiology)
- Mice
- Mice, Knockout
- Pioglitazone
- Polycystic Kidney Diseases
(drug therapy, mortality, pathology)
- TRPP Cation Channels
(genetics)
- Thiazolidinediones
(pharmacology)
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