Abstract | AIM: BACKGROUND: DATA SOURCES: Information was obtained by searching the databases British Nursing Index, CINAHL and Medline. REVIEW METHODS: Selection criteria were as follows: original research in the form of randomized controlled trials; articles had to be written in English; articles had to focus on the effectiveness of naloxone and methylnaltrexone in the treatment of opioid-induced constipation; the search was limited to the period 1990-2008. RESULTS: CONCLUSION: The recent development of methylnaltrexone into a commercially-viable drug indicates its effectiveness. It may help patients suffering from the intense discomfort that constipation can cause.
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Authors | Richard Healy |
Journal | British journal of nursing (Mark Allen Publishing)
(Br J Nurs)
2009 Sep 10-23
Vol. 18
Issue 16
Pg. 998-1002
ISSN: 0966-0461 [Print] England |
PMID | 19773693
(Publication Type: Journal Article, Review)
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Chemical References |
- Narcotic Antagonists
- Narcotics
- Quaternary Ammonium Compounds
- methylnaltrexone
- Naloxone
- Naltrexone
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Topics |
- Constipation
(chemically induced, drug therapy)
- Humans
- Naloxone
(therapeutic use)
- Naltrexone
(analogs & derivatives, therapeutic use)
- Narcotic Antagonists
(therapeutic use)
- Narcotics
(adverse effects)
- Quaternary Ammonium Compounds
(therapeutic use)
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