[A comparative evaluation of the efficacy and tolerance of gold and D-penicillamine preparations in patients with rheumatoid arthritis. II. The effect on the morphological indices of rheumatoid synovitis].

Abstract

Morphological signs of rheumatoid synovitis have been analysed on the basis of 130 puncture biopsies taken from 46 patients prior to the beginning and during parenteral therapy with auric preparations (crysanolom and myocrysin) and peroral administration of an auric preparation rhidaura and small doses of D-penicillamine. The most marked morphological effect was reached in 1.5 years. With a favourable clinical effect all the preparations exhibited capacity for suppressing the following basic signs of rheumatoid synovitis: proliferative changes in the layer of synoviocytes, reaction of blast cells.

• Authors: A B Shekhter, G A Slobodina, A A Krel', M Z Kanevskaia, N V Chichasova
• Journal: Revmatologiia (Moscow, Russia) (Revmatologiia (Mosk)) 1990 Apr-Jun Issue 2 Pg. 23-9; discussion 29-30 ISSN: 0233-7029 [Print] Russia (Federation)
• Vernacular Title: Sravnitel'naia otsenka éffektivnosti i perenosimosti preparatov zolota i D-penitsillamina u bol'nykh revmatoidnym artritom. Soobshchenie II. Vliianie na morfologicheskie priznaki revmatoidnogo sinovita.
• PMID: 1977194 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antirheumatic Agents
• Organogold Compounds
• Penicillamine

Topics

• Adult
• Antirheumatic Agents (therapeutic use)
• Arthritis, Rheumatoid (drug therapy, pathology)
• Female
• Humans
• Male
• Middle Aged
• Organogold Compounds
• Penicillamine (therapeutic use)
• Synovitis (drug therapy, pathology)