[Expression and significance of VCAM-1 in subjects with allergic inflammation of respiratory tract].

Abstract

OBJECTIVE:

To study the expression and significance of vascular cell adhesion molecule-1 (VCAM-1) in subjects with allergic inflammation of respiratory tract.

METHOD:

Thirty-nine subjects with allergic rhinitis and asthma (allergic rhinitis and asthma group) and twenty-one subjects with only allergic rhinitis (allergic rhinitis group) were divided into two group. Bronchial and nasal biopsy specimens were taken and were stained with HE. The expression of VCAM-1 in nasal and bronchial mucosa was detected by immunohistochemistry technique.

RESULT:

The amounts of eosinophils within bronchial mucosa of allergic rhinitis and asthma group were significantly higher than that of allergic rhinitis group (t=12.81, P<0.01). The difference of VCAM-1 expression between allergic rhinitis group and allergic rhinitis and asthma group was not statistically significant . The amounts of VCAM-1 positive cell in bronchial mucosa of allergic rhinitis and asthma group were significantly higher than that of allergic rhinitis group (t=9.43, P<0.01). The number of VCAM-1 positive cells in bronchial mucosa was significantly positively correlated with the number of eosinophils in bronchial mucosa of allergic rhinitis and asthma group (r=0.783, P<0.01).

CONCLUSION:

This study shows that upregulation of VCAM results in generalized airway inflammation in patients with allergic rhinitis.

• Authors: Yuanyuan Wang, Minghui Zhou, Weihua Lou
• Journal: Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi) Vol. 23 Issue 11 Pg. 506-7, 512 (Jun 2009) ISSN: 2096-7993 [Print] China
• PMID: 19771922 (Publication Type: English Abstract, Journal Article)

Chemical References

• Vascular Cell Adhesion Molecule-1

Topics

• Adult
• Asthma (complications, metabolism)
• Female
• Humans
• Inflammation
• Male
• Middle Aged
• Nasal Mucosa (metabolism)
• Rhinitis (complications, metabolism)
• Vascular Cell Adhesion Molecule-1 (metabolism)