Clinical and molecular epidemiology of methicillin-resistant Staphylococcus aureus carrying SCCmecIV in a university hospital in Porto Alegre, Brazil.

Abstract	We evaluated clinical outcomes and molecular epidemiology of methicillin-resistant Staphylococcus aureus carrying SCCmecIV recovered from patients who attended at a teaching hospital from Porto Alegre, Brazil. All Panton-Valentine leukocidin (PVL)-producer isolates belonged to clonal complex (CC) 30 (11 isolates, related to Oceania Southwest Pacific clone [OSPC]), and the PVL-negative isolates were typed as CC5 (2 isolates, related to the pediatric clone). Five patients had health care-associated infections (HCAIs) with hospital-onset, 5 HCAIs with community-onset, and 3 community-acquired infections without risks. A high overall mortality (30.8%) was found. This study show that OSPC isolates are not only causing community-associated infections but are also involved in HCAI in our country.
Authors	Letícia V Scribel, Maria C Silva-Carvalho, Raquel Rodrigues Souza, Silvana V Superti, Carlos H C Kvitko, Agnes M S Figueiredo, Alexandre P Zavascki
Journal	Diagnostic microbiology and infectious disease (Diagn Microbiol Infect Dis) Vol. 65 Issue 4 Pg. 457-61 (Dec 2009) ISSN: 1879-0070 [Electronic] United States
PMID	19766425 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Anti-Bacterial Agents Bacterial Toxins DNA, Bacterial Exotoxins Leukocidins Panton-Valentine leukocidin
Topics	Adolescent Adult Aged Aged, 80 and over Anti-Bacterial Agents (pharmacology) Bacterial Toxins (biosynthesis) Brazil (epidemiology) Child Child, Preschool Chromosomes, Bacterial (genetics) Cluster Analysis Community-Acquired Infections (epidemiology, microbiology, mortality) Cross Infection (epidemiology, microbiology, mortality) DNA Fingerprinting DNA, Bacterial (genetics) Electrophoresis, Gel, Pulsed-Field Exotoxins (biosynthesis) Female Genotype Hospitals, University Humans Leukocidins (biosynthesis) Male Methicillin-Resistant Staphylococcus aureus (classification, genetics, isolation & purification) Microbial Sensitivity Tests Middle Aged Molecular Epidemiology Staphylococcal Infections (epidemiology, microbiology, mortality) Young Adult

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