Immune response in lung cancer mouse model mimics human anti-Hu reactivity.

Abstract

Most patients with paraneoplastic encephalomyelitis/sensory neuronopathy PEM/SN have small-cell lung cancer (SCLC) and develop antibodies against neuronal-specific Hu proteins, which are abnormally expressed in the tumor. Anti-Hu reactivity is present in ~16% of SCLC patients without PEM/SN. Here we test the hypothesis that engineered SCLC-prone mice may exhibit anti-Hu reactivity. We show that tumors from SCLC-prone mice misexpress Hu proteins, and 14% of mice harbor anti-Hu antibodies. Mice appear to show reactivity prior to clinical diagnosis of SCLC. This mouse model system will be useful to study SCLC-associated autoimmunity, its diagnostic value, and the potential protective role of oncoantigen-directed autoantibodies.

• Authors: Meleeneh Kazarian, Joaquim Calbo, Natalie Proost, Catherine L Carpenter, Anton Berns, Ite A Laird-Offringa
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 217 Issue 1-2 Pg. 38-45 (Dec 10 2009) ISSN: 1872-8421 [Electronic] Netherlands
• PMID: 19765830 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies
• Autoantibodies
• ELAV Proteins
• RNA, Messenger
• Vaccines, DNA
• Luciferases

Topics

• Animals
• Antibodies (blood)
• Autoantibodies (immunology, metabolism)
• Disease Models, Animal
• ELAV Proteins (genetics, immunology)
• Humans
• Luciferases (genetics)
• Lung Neoplasms (blood, immunology, mortality)
• Magnetic Resonance Imaging
• Mice
• Neoplasm Transplantation (immunology)
• RNA, Messenger (metabolism)
• Small Cell Lung Carcinoma (blood, immunology, mortality)
• Survival Analysis
• Time Factors
• Vaccines, DNA (immunology)