Abstract | BACKGROUND:
Hypertension and obesity are highly prevalent among African Americans (AAs). We have previously reported that both plasma aldosterone (PA) and body mass index (BMI) are higher in hypertensive than in normotensive AAs. This study evaluates the relative contributions of adiposity and PA to hypertension in AAs. METHODS: A total of 466 AAs (50% hypertensive, 51% women) were evaluated in a Clinical Research Center by stratifying them into three subgroups based on BMI (normal weight, overweight, and obese). Anthropometric measurements, ambulatory blood pressure (BP), fasting glucose, insulin, 24-h urine sodium and potassium, creatinine clearance, standing PA and plasma renin activity (PRA) were measured. Insulin resistance was estimated by the homeostasis model assessment. RESULTS: Compared to normotensives, hypertensives had higher BMI, waist circumference (WC), and were more insulin resistant (P < or = 0.01). When stratified by BMI, hypertensives in each BMI strata had higher PA (P < or = 0.05) and lower PRA (P < or = 0.01) compared to normotensives. Compared to normotensives, WC was greater in overweight and obese hypertensives, but not in normal-weight hypertensives. In the overall sample, age, WC, PA, and PRA were the major contributors to BP variance and to hypertension. Among normal-weight subjects, PA and PRA significantly predicted BP and the odds ratio for hypertension, whereas WC had no predictive value. CONCLUSIONS:
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Authors | Srividya Kidambi, Jane M Kotchen, Shanthi Krishnaswami, Clarence E Grim, Theodore A Kotchen |
Journal | American journal of hypertension
(Am J Hypertens)
Vol. 22
Issue 12
Pg. 1303-8
(Dec 2009)
ISSN: 1941-7225 [Electronic] United States |
PMID | 19763119
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
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Topics |
- Adult
- Black or African American
- Aldosterone
(blood)
- Blood Pressure
- Body Mass Index
- Cross-Sectional Studies
- Female
- Humans
- Hypertension
(blood, physiopathology)
- Insulin Resistance
(physiology)
- Male
- Middle Aged
- Obesity
(complications, physiopathology)
- Overweight
(complications)
- Waist Circumference
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