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Adenosine receptors as targets for therapeutic intervention in asthma and chronic obstructive pulmonary disease.

Abstract
Asthma and chronic obstructive pulmonary disease (COPD) are pulmonary disorders characterized by various degrees of inflammation and tissue remodeling. Adenosine is a signaling molecule that is elevated in the lungs of patients with asthma and COPD. Adenosine elicits its actions by engaging cell surface adenosine receptors, and substantial preclinical evidence suggests that targeting these receptors will provide novel approaches for the treatment of asthma and COPD. Studies in animal models of airway disease suggest that there may be clinical benefit to the use of A(1), A(3) and A(2B) adenosine receptor antagonists in the treatment of features of asthma and/or COPD, while A(2A) agonists may also prove effective. Several adenosine receptor based pharmacologic agents have entered clinical development for the treatment of asthma and COPD; however, the studies have been limited and the efficacy of such approaches is not yet clear.
AuthorsRiccardo Polosa, Michael R Blackburn
JournalTrends in pharmacological sciences (Trends Pharmacol Sci) Vol. 30 Issue 10 Pg. 528-35 (Oct 2009) ISSN: 1873-3735 [Electronic] England
PMID19762093 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Purinergic P1 Receptor Agonists
  • Purinergic P1 Receptor Antagonists
Topics
  • Animals
  • Asthma (drug therapy)
  • Humans
  • Pulmonary Disease, Chronic Obstructive (drug therapy)
  • Purinergic P1 Receptor Agonists
  • Purinergic P1 Receptor Antagonists

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