Abstract | BACKGROUND: METHODS: We studied 24 white adult Japanese rabbits at the animal facility at the Medical College of Wuhan University. Rabbits were randomly assigned into a sham-operation group (group I), an IR group (group II), and an etomidate-treated IR group (group III). Rabbits in groups II and III were subjected to 45 min of infrarenal aortic cross-clamping to induce spinal cord ischemia, while group I rabbits received the sham operation as a control. Following an initial single-dose intravenous injection at 0.6 mg/kg 10 min before aortic clamping, etomidate was infused intravenously at 3mg/(kg . hr) in group III rabbits until unclamping, while 0.9% saline was given as the control in group II. RESULTS: Changes in neurological function scores, histopathology, electromyography, malondialdehyde levels, superoxide dismutase activities, and the concentrations of Ca(2+), Mg(2+), Cu(2+), and Zn(2+) ions were measured. Compared with the sham-operation group, group II showed significant IR injury-associated changes in all parameters evaluated (p<0.01), whereas these unfavorable changes were significantly reversed in etomidate-treated animals (p<0.05 or p<0.01). No significant differences were observed between group I and group III animals in all parameters. CONCLUSION:
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Authors | Qijing Yu, Qingshan Zhou, Haibo Huang, Yanlin Wang, Shufang Tian, Daiming Duan |
Journal | Annals of vascular surgery
(Ann Vasc Surg)
Vol. 24
Issue 2
Pg. 225-32
(Feb 2010)
ISSN: 1615-5947 [Electronic] Netherlands |
PMID | 19748211
(Publication Type: Journal Article)
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Copyright | Copyright 2009 Annals of Vascular Surgery Inc. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Anesthetics, Intravenous
- Antioxidants
- Neuroprotective Agents
- Malondialdehyde
- Copper
- Superoxide Dismutase
- Magnesium
- Zinc
- Calcium
- Etomidate
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Topics |
- Anesthetics, Intravenous
(pharmacology)
- Animals
- Antioxidants
(administration & dosage, pharmacology)
- Aorta
(surgery)
- Calcium
(metabolism)
- Copper
(metabolism)
- Disease Models, Animal
- Electromyography
- Etomidate
(administration & dosage, pharmacology)
- Female
- Hindlimb
- Infusions, Intravenous
- Injections, Intravenous
- Ligation
- Magnesium
(metabolism)
- Male
- Malondialdehyde
(metabolism)
- Muscle, Skeletal
(innervation)
- Neurologic Examination
- Neuroprotective Agents
(administration & dosage, pharmacology)
- Rabbits
- Reperfusion Injury
(etiology, metabolism, pathology, physiopathology, prevention & control)
- Spinal Cord
(blood supply, drug effects, metabolism, pathology, physiopathology)
- Spinal Cord Ischemia
(complications, drug therapy, metabolism, pathology, physiopathology)
- Superoxide Dismutase
(metabolism)
- Zinc
(metabolism)
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